Synthèse, stabilité et toxicité de quantum dots à coeur CdSe

Abstract : Due to their unique properties compared to their bulk counterparts, nanomaterials have gained considerable attention, especially in industry and medicine. Their fast development has generated many public concerns, especially because of a lack of knowledge regarding their toxicity. Our project aims to use cadmium selenide (CdSe) as a model material in order to initiate a research aiming at establishing a correlation between the nanoparticles chemical structure, their surface reactivity, their stability and their toxicity. CdSe and alloyed CdSe(S) quantum dots (QDs) were prepared in aqueous phase either at 100°C or under hydrothermal conditions in order to differ solely by their core chemical structure (ternary alloy vs binary semiconductor), while other parameters such as the size, the surface charge or the surface ligand, have been kept constant. Cytotoxicity studies carried out on Escherichia coli have shown that release of Cd2+ played a key role in the toxicity for both QDs. However, alloyed CdSe(S) QDs were also found more stable and less toxic than CdSe nanocrystals. Without disregarding the importance of Cd2+ ions release by the nanoparticles, a correlation between the stability and the production of reactive oxygen species (ROS) showed that toxicity was dependent on QDs photostability. Our study highlights a relationship between the core reactivity, stability and the photo-induced toxicity QD nanoparticles
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Florence-Anaïs Kauffer. Synthèse, stabilité et toxicité de quantum dots à coeur CdSe. Autre [cond-mat.other]. Université de Lorraine, 2014. Français. ⟨NNT : 2014LORR0006⟩. ⟨tel-01750693⟩

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