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Application des fluides supercritiques à la génération de particules

Abstract : This study concems different processes using supercritical fluids for micronization of actives. Three fields being particularly problematic in the pharmaceutical industry were investigated. The first domain to be examined is the processing of molecules having a low solubility in aqueous media. To solve this problem, the RESS and ASES processes were used and allowed to produce submicronic particles with various shape and structure. Experimental results confirmed that particle size reduction helps to enhance the dissolution kinetic. Additionaly, two new processes, based on complexation with cyclodextrine derivatives, were successfully developed to increase water solubility of low-soluble molecules. In a second step, an original process allowed to form microparticles of protein with controlled delivery. By changing process parameters, delivery could be delayed from minutes to hours while protein activity was conserved. In a last part, a new process using emulsions was tested to form fine biomolecules particles using aqueous solutions. The combination of the emulsion and the supercritical fluid advantages allowed to produce dry particles while keeping their activity
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Jennifer Jung. Application des fluides supercritiques à la génération de particules. Autre. Institut National Polytechnique de Lorraine, 2001. Français. ⟨NNT : 2001INPL106N⟩. ⟨tel-01752275⟩



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