Quantification de la vascularisation de l'unité utéro-placentaire par Doppler 3D : évaluation clinique et expérimentale

Abstract : Placental vascular pathologies (PVP), preeclampsia (PE) and intra uterine growth restriction (IUGR), are a major cause of maternal and perinatal morbidity and mortality in developed countries. A default of utero-placental vascularization is present in these two pathologies. 3D Power Doppler (3DPD) is an easy tool to use in clinic, its quantitative indices calculated from obtained utero-placental volume seem promising for PE prediction. The major objective of this thesis was to evaluate the discriminative value of this technique between physiological and pathological situations, as well as its limitations in clinical and animal models. The screening performance of PE and/or IUGR by 3DPD indices in the first trimester was studied in a prospective multicenter study. An evaluation of the correlation between 3DPD indices and morphometric indices was then carried out among pregnant women at term. At the end, the interest of the technique was demonstrated in an ewe model of IUGR (treated with testosterone).
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Jie Duan. Quantification de la vascularisation de l'unité utéro-placentaire par Doppler 3D : évaluation clinique et expérimentale. Médecine humaine et pathologie. Université de Lorraine, 2016. Français. ⟨NNT : 2016LORR0088⟩. ⟨tel-01752337⟩

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