Nouvelle approche vers la synthèse de l'acide 5-(-2-oxo-2,3-dihydro-1H-thiéno[3,4-d]imidazol-4-yl) pentanoïque (la tétradéhydrobiotine)

Abstract : Intracellular biotin is a coenzyme in carbon dioxyde transport. Futhermore because of their high affinity, avidin-biotin or streptavidin-biotin coupling is often used in different biochemical analyses such as protein purification and detection. The high avidin/streptavidin-biotin affinity can also constitute a drawback since proteins require to be denaturated in order to be released, and therefore are often lacking activity. In order to identify pure and active proteins target using this methodology, our aim was to synthesize an analog of biotin: 2,3,4,5-tetradehydrobiotin. We have isolated different key intermediates for the synthesis of tetradehydrobiotin. During this study we also synthesize news thieno[2,3-d]imidazolones starting from hydantoin
Document type :
Theses
Complete list of metadatas

Cited literature [37 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/tel-01752694
Contributor : Thèses Ul <>
Submitted on : Thursday, March 29, 2018 - 1:54:38 PM
Last modification on : Monday, April 16, 2018 - 10:42:33 AM

File

Ba_Lalla.Aicha.SMZ0745.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01752694, version 1

Collections

Citation

Lalla Aïcha Ba. Nouvelle approche vers la synthèse de l'acide 5-(-2-oxo-2,3-dihydro-1H-thiéno[3,4-d]imidazol-4-yl) pentanoïque (la tétradéhydrobiotine). Autre. Université Paul Verlaine - Metz, 2007. Français. ⟨NNT : 2007METZ045S⟩. ⟨tel-01752694⟩

Share

Metrics

Record views

18

Files downloads

37