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Etude cinétique du procédé de granulation humide en mélangeur à haut cisaillement

Abstract : In this study of wet granulation process, we are especially interested in binder liquid distribution as a mean to deduce final granule properties. Then, a tracer method is developed to study binder liquid distribution kinetics during granulation process. Granulation experiments are carried out in high shear mixer Mi-Pro using pharmaceutical excipients. The beginning of the process is characterized by heterogeneous binder liquid distribution. Then, liquid redistribution phenomenon is observed according to a first order model. Granule properties (size, porosity, microscopic observation) are found to be similar when binder liquid is homogeneously distributed among different granule classes. Finally operating conditions influence (speed rate, flow rate and wetting criterion) are discussed. In addition, population balances are used as a tool to model experimental results. Agglomeration kernels are presented depending on particle size and binder liquid ratio. Although experimental results could be satisfactorily modelled, population balances show some limitations related to the difficulty of integrating all the study data
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Nadia Smirani. Etude cinétique du procédé de granulation humide en mélangeur à haut cisaillement. Autre. Institut National Polytechnique de Lorraine, 2008. Français. ⟨NNT : 2008INPL021N⟩. ⟨tel-01752990⟩



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