Extension de la réaction «phosphine imide» en série cyclodextrine : Synthèses et propriétés de nouvelles cyclodextrines complexantes

Abstract : In the development of new efficient synthetic processes, the replacement of organic volatile compounds such as hazardous industrial reagents appears as a major gaol in the present day challenge for a green chemistry. It is well know that compounds containing the urea or thiourea functionality are of extended biological. As a powerful easy access to urea functionality and other main quatrivalent functions of chemistry as eg isocyanates, carbodiimide, thiourea or urea notably in CDs series, we earlier reported and demonstrated the high safety, efficiency and versatility of the phosphine imide reaction with free or polymer supported PPH3 and with CS2, CO2 or supercritical CO2. On the second part, specific physico-chemical property related to selective metal coordination and to fluorescence properties of URTF ureido-CDs rare earth complexes were investigated. This new systems were found to have very selective and original coordination processes notably with lanthanide series. For the last part, the synthesis of C2 symmetric receptor including two CDs connected by urea linkers to the chiral diazacrown ether o platform is reported. This molecular system was found to be an efficient complexion tool towards the Busulfan anticancer agent used for the treatment of haematological disorders. A novel bis-guanidinum tetrapode, the first member of a new host family with a checked number of cationic centres and CDs is presented. Its molecular recognition towards nucleodides guest was investigated. The formation of ditopic bimolecular complexe was observed combining host-guest hydrophobic inclusion into CDs and electrostatic interactions between guanidinium and phosphate anion.
Document type :
Theses
File URL :
http://docnum.univ-lorraine.fr/prive/SCD_T_2006_0186_MENUEL.pdf
Complete list of metadatas

https://hal.univ-lorraine.fr/tel-01754278
Contributor : Thèses Ul <>
Submitted on : Friday, March 30, 2018 - 9:43:35 AM
Last modification on : Saturday, March 31, 2018 - 1:24:39 AM

Identifiers

  • HAL Id : tel-01754278, version 1

Collections

Citation

Stéphane Menuel. Extension de la réaction «phosphine imide» en série cyclodextrine : Synthèses et propriétés de nouvelles cyclodextrines complexantes. Autre [cond-mat.other]. Université Henri Poincaré - Nancy 1, 2006. Français. ⟨NNT : 2006NAN10186⟩. ⟨tel-01754278⟩

Share

Metrics

Record views

4