Signalisation intracellulaire dans la régulation des fonctions bactéricides chez les polynucléaires neutrophiles de souris

Abstract : Since the creation of the transgenic mice, the study of the innate immunity of this animal has received renewed interest. To exploit this experimental model as well as possible, it was initially necessary to know its normal function in order to compare to our current knowledge of the human immune system. The aim is to apprehend and define the limits of the murine model. We isolated neutrophils from mouse blood and bone marrow and compared their bactericidal functions. We have shown that mouse bone marrow contains a large population of neutrophils which are morphologically and functionally as mature as blood neutrophils. In addition, the discovery of new molecules aiming at stimulating the microbicidal activity of neutrophils as well as the study of intracellular signalling pathways leading to either the activation of these cells, their survival or their accelerated death, allowed us to better understand their regulation.
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Rachel Boxio. Signalisation intracellulaire dans la régulation des fonctions bactéricides chez les polynucléaires neutrophiles de souris. Sciences agricoles. Université Henri Poincaré - Nancy 1, 2005. Français. ⟨NNT : 2005NAN10006⟩. ⟨tel-01754337⟩

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