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Incidence de la sclérose en plaques en Lorraine : fatigue et autres facteurs d'incapacité dans la cohorte LORSEP

Abstract : Multiple sclerosis (MS) is the most disabling neurological disease in young adults. We set out to determine its epidemiologic characteristics, to study MS related fatigue and to define the principal predictive clinical factors of disability. To do this, we set up the LORSEP Cohort: a continuous register of incident and prevalent cases in Lorraine which we followed prospectively. On December 31, 2004, the prevalence of MS was 117 per100 000 inhabitants (95% CI: 116 to 118). The average incidence, adjusted by age and gender, was 5.4 per 100 000 inhabitants (95% CI:4.3-6.5) during the period 1990-2004. During this period, the incidence increased among women but not among men. We used a French validated version of the Modified Fatigue Impact Scale (MFIS-SEP) which was adapted from the internationally referenced Fisk scale. It comprises four dimensions some of which are correlated with disability. The reproducibility of the EMIF-SEP was good. Three predictive factors of disability of MS not previously described were identified. These are that 1/ relapses in c1inical separate areas are a predictive factor of early disability 2/ the physical dimension of fatigue is predictive of greater disability at 3 years (unlike other dimensions) 3/ MS patients of North-African origin appear to develop greater disability than patients of European origin. The LORSEP Cohort now constitutes an effective working tool which will allow epidemiological surveillance, future clinical and biological studies and the assessment of health measures introduced in Lorraine.
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Submitted on : Friday, March 30, 2018 - 9:46:27 AM
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Marc Debouverie. Incidence de la sclérose en plaques en Lorraine : fatigue et autres facteurs d'incapacité dans la cohorte LORSEP. Médecine humaine et pathologie. Université Henri Poincaré - Nancy 1, 2006. Français. ⟨NNT : 2006NAN11312⟩. ⟨tel-01754356⟩



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