Anomalies géniques de l'épithélium respiratoire : applications dans la carcinogenèse bronchique et la mucoviscidose

Abstract : Recent advances about gene abnormality knowledge in respiratory disease allow new approches especially in non small celi lung cancer and cystic fibrosis. Thus, we investigated new markers for lung cancer prognosis (ras, bcl2, p53, c-erb-b2 genes), and the causes of chemoprevention failure using retinoids such as loss of heterozygoty or retinoic acid receptor [bêta] gene promoter hypermethylation. Concerning cystic fibrosis inflammation, processes, bacterial adherence vvas shown tobe of major importance although a direct (endogenous) contribution of the CFTR gene ddect cannot he ruled out. Nuclear transcription factor NF[kappa]B activation and interleuk.in-8 secretion were lowered in vitÎo after gene transfer.
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Philippe Scheid. Anomalies géniques de l'épithélium respiratoire : applications dans la carcinogenèse bronchique et la mucoviscidose. Sciences agricoles. Université Henri Poincaré - Nancy 1, 2002. Français. ⟨NNT : 2002NAN10305⟩. ⟨tel-01754376⟩

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