Skip to Main content Skip to Navigation
Theses

Élaboration de nanocapsules par polymérisation radicalaire contrôlée à partir d’un tensioactif réactif dérivé du dextrane

Abstract : Biocompatible nanocapsules (NCs) for intravenous administration of hydrophobic anticancer agents were produced by interfacial Reversible Addition-Fragmentation chain Transfer (RAFT) miniemulsion polymerization. Controlled growth of polymeric grafts constituting NCs shell was obtained using a multi-reactive dextran-based transurf called DexN3-[tau]CTA[gamma] (acting both as macroRAFT agent and surfactant) to mediate RAFT polymerization at the liquid/liquid interface. NCs composed of a hydrophobic polymer shell (poly(methyl methacrylate)), an oily liquid core (Miglyol®810) and a hydrophilic polysaccharide coating (dextran) were obtained. These nano-objects were characterized in terms of size, dextran coverage (density, thickness and stability), colloidal stability and morphology. Synthesis of NCs with a pH-sensitive polymer shell was approached. Finally, potential of these nano-objects for biomedical applications was evaluated by studies on different aspects: i) encapsulation and delivery of a model active substance, ii) NCs cytotoxicity, iii) NCs interactions with plasma proteins, and iv) surface functionalization of NCs by “click chemistry”.
Document type :
Theses
File URL :
http://docnum.univ-lorraine.fr/public/DDOC_T_2016_0086_FORERO_RAMIREZ.pdf
Complete list of metadata

https://hal.univ-lorraine.fr/tel-01754664
Contributor : Thèses Ul <>
Submitted on : Friday, March 30, 2018 - 9:56:49 AM
Last modification on : Tuesday, March 30, 2021 - 3:24:41 AM

Identifiers

  • HAL Id : tel-01754664, version 1

Collections

Citation

Laura Marcela Forero Ramirez. Élaboration de nanocapsules par polymérisation radicalaire contrôlée à partir d’un tensioactif réactif dérivé du dextrane. Alimentation et Nutrition. Université de Lorraine, 2016. Français. ⟨NNT : 2016LORR0086⟩. ⟨tel-01754664⟩

Share

Metrics

Record views

100