Intensification des procédés de synthèse des produits de contraste et application à leur fabrication industrielle en continu

Abstract : Preventing diagnostics are increasing and so is the demand for contrast media while its industrial cost needs to be decreased for competitiveness reasons. The synthesis route for a contrast media used in X-ray medical imaging, an iodinated molecule with hydrophilic functional groups, is made of several reactions: some of them are limited by heat transfer (exothermic reactions) or/and mass transfer (multiple-phase media) while others are kinetically limited. The use of continuous intensified equipment leads to enhanced heat and mass transfer performances while keeping good selectivity and reproducibility. The synthesis route is globally modified in the first place in order to shift from batch to continuous intensified and the reactions are classified for local intensification studies. A combined approach based on experimental measurements and simulation enables the building of reaction models which can be used as a guideline for the experiments towards finding the operating conditions that lead to the desired performances at laboratory scale. The new synthesis route production is based on an alternation between continuous and discontinuous steps, which leads to difficult production management. New prospects are created with a new hydrophilic synthesis route, where the limitations for shifting from batch to continuous due to the presence of solids are solved and the whole synthesis route can be transferred from batch to continuous mode
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Ivana Dobrosavljevic. Intensification des procédés de synthèse des produits de contraste et application à leur fabrication industrielle en continu. Alimentation et Nutrition. Université de Lorraine, 2016. Français. ⟨NNT : 2016LORR0022⟩. ⟨tel-01754673⟩

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