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Influences de l'aldostérone et l'angiotensine II dans le contrôle central de l'appétit spécifique pour le sodium chez le rat Zucker obèse

Abstract : Zucker rats have a recessive mutation in the gene fa/fa that suppresses the leptin receptor and thus it presents similarities with human obesity via its metabolic syndrome. Known for its sensitivity to sodium Zuckers have a predisposition to develop hypertension. It is thus an ideal model to study the synergistic influences of aldosterone and angiotensin II (AngII), the two principal hormones of the renin-angiotensinaldosterone. (SRAA) system, as well as the role that obesity plays in the regulation of sodium appetite (ASS). Obese Zucker rats prefer isotonic to hypertonic NaCl and under dehydration and/or high temperature conditions regulate hydromineral balance by increasing significantly intake of water and NaCl. Depleted of sodium with a diuretic female Zucker rats show a greater sodium appetite than males. Despite their increased weight obese Zucker rats regulate their sodium and hydrational balance similar to the lean genetic controls. Central injection of a low dose of AngII stimulates consumption of water but not sodium in Zucker rats. However, peripheral mineralocorticoid combined with a central injection of Angli stimulates a significant ASS, greater in obese than lean Zucker rats. DOCA increases also the sensitivity of spontaneously active neurons to locally applied Angli in the septum and subfornical organ. Furthermore, obese Zucker rats have a higher background plasma aldosterone level than lean rats. These results suggest that aldosterone may be the principal hormone of the SRAA that plays a key role in the regulation of an ASS in obese Zucker rats. This increased central sensitivity to AngII and thus sodium may be the basis of their predisposition to hypertension.
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http://docnum.univ-lorraine.fr/prive/SCD_T_2007_0049_OMOUESSI.pdf
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https://hal.univ-lorraine.fr/tel-01775362
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Submitted on : Tuesday, April 24, 2018 - 3:29:37 PM
Last modification on : Wednesday, June 3, 2020 - 2:12:03 PM

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  • HAL Id : tel-01775362, version 1

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Serge Thierry Omouessi. Influences de l'aldostérone et l'angiotensine II dans le contrôle central de l'appétit spécifique pour le sodium chez le rat Zucker obèse. Neurosciences [q-bio.NC]. Université Henri Poincaré - Nancy 1, 2007. Français. ⟨NNT : 2007NAN10049⟩. ⟨tel-01775362⟩

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