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Contribution à l'étude expérimentale des effets de sels aluminiques chez le rat en développement

Abstract : In the first part, pregnant rats were treated orally aluminium lactate during three periods of gestation to determine the treatment's influence on mortality, weight gain, neuromotor maturation and learning abilities (operant conditioning and radial arm maze tests) of their pups. The variations of some mineral elements (Al, P, Ca, Cu, Zn and Mg). Were also studied in plasma, urine and organs (brain, liver, spleen and kidneys) of pregnant and non pregnant female rats. The elements were also measured in the whole foetus from treated or not treated dams. In the second part, various elements concentrations were evaluated in plasma and some organs of adult rats after intraperitoneal (ip) administration of aluminium chloride. The consequences of a daily ip injection of Al chloride to female rats during the 12 days after parturition upon the amount of Al in milk were particularly studied in this chapter. The aluminium levels in plasma and some organs of the dams and pups were also measured
Mots-clés : Aluminium-Toxicologie
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  • HAL Id : tel-01775466, version 1



Guy Muller. Contribution à l'étude expérimentale des effets de sels aluminiques chez le rat en développement. Toxicologie. Université Paul Verlaine - Metz, 1993. Français. ⟨NNT : 1993METZ022S⟩. ⟨tel-01775466⟩



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