Caractérisation par microsonde laser LAMMA de poussières de mine de charbon et recherche de nouveaux paramètres de nocivité spécifique

Abstract : Etiopathogenesis and the role of quartz in the development of coalworkers' pneumoconiosis (improperly called "silicosis") are still a matter of debate. Epidemiological or experimental toxicity and/or non-quartz related toxic determinants. Our methodological approach relates to single particle analysis of coal mine dusts using laser microprobe mass analysis. It is based on the determination of the incidence (within a particle population) of elements (or combinations thereof) which reveal a correlation with epidemiological or experimental toxicity data. Results demonstrate (in agreement with former studies) that surface contaminations of quartz may be considered as a parameter of specific harmfulness (i.e. in agreement with epidemiological data) which modulate the quartz-related toxicity of coal mine dusts. However, most of the results suggest that iron (and other heavy metals) is a more relevant toxicity determinant. An etiopathogenic hypothesis and a toxic principle based on surface-related oxydative properties of dusts particles are presented (as actually discussed for asbestos fibres). This work opens new perspectives in indutrial hygiene for studies aiming at the assessment of occupational exposure limits in mining industries
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Jean-Luc Tourmann. Caractérisation par microsonde laser LAMMA de poussières de mine de charbon et recherche de nouveaux paramètres de nocivité spécifique. Médecine humaine et pathologie. Université Paul Verlaine - Metz, 1993. Français. ⟨NNT : 1993METZ018S⟩. ⟨tel-01775477⟩

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