Contribution à l'étude ethnopharmacologique et étude pharmacologique d'Euphorbia hirta L. : propriétés psychotropes, analgésiques, anti-pyrétiques et anti-inflammatoires

Abstract : The following procedures have been conducted : the bibliographical synthesis of the traditional therapeutic indications of Euphorbia hirta L. of previous botanical, toxicological, chemical and pharmacological studies, the verification of some of this data and the realisation of a pharmacological study initially orientad on the psychotropic properties. The botanical characteristics of Euphorbiaceae, the low toxicity of Euphorbia hirta L., the presence of the various chemical groups previously isolated (polyphenols,terpenes, organic acids, amino acids, saccharids, saponosids, inorganic salts), and the absence of alcaloids and cyanogentic by-products, have been confirmed. A mong the numerous traditional indications of E. hirta L. mentioned in literature (gastro-intestinal, genital, skin and mucosa, kidney and liver affections; cardio-respiratory troubles ; sedative, analgesic, febrifuge and anti-inflammatory properties), the study of psychotropic effects has resulted in the discovery of sedative effects beginning with 100 mg/Kg, dose-dependent, (forced exploration and free exploration tests on mice), and of light anxiolytic effects with low doses (25 and 12.5 mg/kg). The absence of hypnotic, neuroleptic, anti-depressive, anti_histaminic, anti_convulsivant and myorelaxant properties, as well the absence of affinity for benzodiazepine receptors (in vivo and in vitro techniques) enable to suggest a psychopharmacological profile such as non-benzodiazepine minor tranquilizer. Considering these results and because of the frequent coexistence of sedative effects and analgesic effects for E. hirta L., the following facts have been brought to light : a morphinometic central analgesic activity starting with 20mg/Kg and anti pyretic and anti-inflammatory effects in acute processes (100 mg/kg). The existence of a tolerance to sedative and analgesic effects and the absence of cross-tolerance with morphine have been proven. Taken orally E. hirta L. is efficient only after dissolution in a labrafil-type excipient
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Marie-Claire Lanhers. Contribution à l'étude ethnopharmacologique et étude pharmacologique d'Euphorbia hirta L. : propriétés psychotropes, analgésiques, anti-pyrétiques et anti-inflammatoires. Médecine humaine et pathologie. Université Paul Verlaine - Metz, 1988. Français. ⟨NNT : 1988METZ020S⟩. ⟨tel-01775566⟩

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