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Contribution à l'étude expérimentale des effets d'intoxication aluminiques chez le rat : développement physique, maturation neuromotrice, comportement en situations d'apprentissage

Abstract : Aluminum, a potent toxic substance of the central nervous system has been especially studied for 20 years in human clinic and animal experimentation. Yet, the scarcity of works in the ontegenetic field of aluminum intoxication lead us to study the effects of this element when applied to rats in early period of life : in utero by intoxication of the pregnant female (by aluminum chloride or lactate) or during the pre-weaning period (by aluminum lactate). A set of parameters including neuro-motor maturation tests and learning abilities tests were used in order to evaluate the short- and long-term consequences of these treatments. The results indicate that when treated in utero all the pups of a litter have losses of weight which include a post-natal letality under a critical level of birth weight. Surviving pups have an initial delay in their neuro-motor development which completely disappears in aluminum chloride treated rats. Aluminum lactate treated rats have some long term sequels, which are revealed by learning abilities tests (operant conditioning and spatial learning). Post-natally treated rats show the same syndrome at a greater degree. The dose-dependant weight losses which occur although the pups eat maternal milk seems imply a negative effect of Al upon the gastrointestinal tract. X-ray microanalysis indicates modifications of Zn and Cu levels and indicate the direction of further studies
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Viviane Bernuzzi. Contribution à l'étude expérimentale des effets d'intoxication aluminiques chez le rat : développement physique, maturation neuromotrice, comportement en situations d'apprentissage. Biologie du développement. Université Paul Verlaine - Metz, 1988. Français. ⟨NNT : 1988METZ009S⟩. ⟨tel-01775752⟩

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