Recherche et évaluation de l'activité biologique des substances végétales sur le S.N.C. chez la souris, in vivo et vis-à-vis des récepteurs cholinergiques, histaminergiques et opoïdes, in vitro, au niveau du duodenum de rat et de l'iléon de cobaye

Abstract : A bibliography study permetted us to select 8 species, Melissa officinalis, Passiflora incarnata, Euphorbia hirta, Eschscholtzia californica and Fagarazanthoxyloïds for their sedative, anxiolytic and analgesic effects ; Annona reticulatla, Peumus boldus and Fumaria officinalis for their antistaminic and antispasmodic effects. Sedative, anxiolytic and analgesic thera peutic indications of Melissa officinalis, Passiflora incarnata Euphorbia hirta, Eschscholtzia californica and Fagara Zanthoxyloïdes have been scientifically confirmed by pharmacological investigation in vivo in the mouse. Antispasmodical effects of Melissa officinalis, Peumus boldus, Annona reticulatla and Fumaria officinalis have been confirmed by pharmacological tests in vivo and in vitro for. Several obtained from Melissa officinalis'extract or the pure natural substances contained in passiflora incarnata did not allowed to find the sedative and anxiolytic properties observed with crude extracts. Sedative properties of 4 plants were not related to antihistaminical effects demonstrated wich isolated guinea-pig ileum. The effect of plant extracts with analgesic properties demonstrated in vivo have been tested in vitro in guinea-pig ileum towards opioïd receptors. Thus, Euphorbia hirta was the single plant which bind with opioïd receptors. Eschscholtzia californica, Fagara zanthoxyloides and Melissa officinalis'extracts are probably not related with opioïd receptors wich probably not be involved in the mechanism of action of actio of their analgesic activity
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Rachid Soulimani. Recherche et évaluation de l'activité biologique des substances végétales sur le S.N.C. chez la souris, in vivo et vis-à-vis des récepteurs cholinergiques, histaminergiques et opoïdes, in vitro, au niveau du duodenum de rat et de l'iléon de cobaye. Médecine humaine et pathologie. Université Paul Verlaine - Metz, 1992. Français. ⟨NNT : 1992METZ001S⟩. ⟨tel-01775951⟩

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