Hypervariabilité génétique chez streptomyces ambofaciens: Plasticité d'un arc génomique

Abstract : The wild-type (WT) strain Streptomyces ambofaciens DSM40697 exhibits a high degree of genetic instability. Pigment-defective colonies were spontaneously generated from the wild-type colonies at the frequency of 0.01. While only 13% of these pigment-defective colonies gave rise to homogeneous progeny exhibiting the mutant parental phenotype, 87 % of the mutant colonies gave rise to heterogeneous progeny without a preponderant phenotupe. This new aspect of genetic instability was called hypervariability. In contrast, auxotrophic mutants were obtained from the same WT strain at the frequency that are developmentally-regulated. The close association between genetic instability and giant deletions suggests the dominating part of deletions in the mecanism of genome plasticity and the possible involvement of aprimary mutational event triggering these deletions.
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Pierre Leblond. Hypervariabilité génétique chez streptomyces ambofaciens: Plasticité d'un arc génomique. Génétique. Université Henri Poincaré - Nancy 1, 1990. Français. ⟨NNT : 1990NAN10132⟩. ⟨tel-01777322⟩

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