Apport de la modulation d'intensité et de l'optimisation pour délivrer une dose adaptée aux hétérogénéités biologiques

Abstract : The progress in functional imaging opens new perspectives in the delineation of target volumes in radiotherapy. We can intend to adapt the irradiation doses on the tumor activity and to perform a dose escalation. Our objectives were (i) to characterize the TEP thresholding, by quantifying the uncertainties of the target volume contour, (ii) to set up the geometry suited, (iii) to estimate the dosimetric impact of this new protocol and (iv) to verify that dosimetry is perfectly distributed. 3 original phantoms and 2 virtual phantoms containing 3 dose levels were specially created. The diameter of 1cm for the 3rd level was able to be reached. A dose escalation of 20Gy was possible. The dosimetric impact on two real cases was suitable. The clinical tolerances were respected. So all the treatment process was estimated and validated. However such doses should be carefully estimated before being prescribed clinically and progress is also expected in imaging
Document type :
Theses
Complete list of metadatas

Cited literature [180 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/tel-01777348
Contributor : Administrateur Du Ccsd <>
Submitted on : Tuesday, April 24, 2018 - 4:18:17 PM
Last modification on : Saturday, May 5, 2018 - 1:07:00 AM
Long-term archiving on : Wednesday, September 19, 2018 - 4:16:57 PM

File

2007_KUBS_F.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : tel-01777348, version 1

Collections

Citation

Fleur Kubs. Apport de la modulation d'intensité et de l'optimisation pour délivrer une dose adaptée aux hétérogénéités biologiques. Médecine humaine et pathologie. Institut National Polytechnique de Lorraine, 2007. Français. ⟨NNT : 2007INPL066N⟩. ⟨tel-01777348⟩

Share

Metrics

Record views

29

Files downloads

28