Pronostic factors on MRI in patients with acute ischemic stroke

Abstract : MRI plays an important role in evaluating ischemic stroke and determining the treatment strategies. Diffusion weighted imaging and perfusion weighted imaging are two essential sequences in ischemic stroke assessment. The principal objective of this work was to study the predictive role of MRI in ischemic stroke, including the role of MRI-derived parameters in tissue viability prediction; the relationship of the ischemic lesional volume and the functional outcome and mechanical thrombectomy efficacy; and the impact of the pretreatment ischemic location on functional outcome after mechanical thrombectomy. Our results suggested that apparent diffusion coefficient and relative cerebral blood flow were potential candidates to predict tissue viability; pretreatment lesional volume was an independent predictor for functional outcome; the clinical benefit of adding mechanical thrombectomy to thrombolysis decreased with the increase of lesional volume; however, patients with large lesional volume could still benefit from reperfusion treatment; the pretreatment ischemic location provided important prognostic information for functional outcome. The overall results of the thesis provided a better understanding of the role of MRI in acute ischemic stroke assessment, especially in patients treated with mechanical thrombectomy. Our work provided new perspective in clinical application of MRI and suggested future research of ischemic stroke imaging
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Theses
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http://docnum.univ-lorraine.fr/ulprive/DDOC_T_2018_0143_XIE.pdf
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https://hal.univ-lorraine.fr/tel-01928470
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Submitted on : Tuesday, November 20, 2018 - 3:25:27 PM
Last modification on : Wednesday, November 21, 2018 - 1:18:16 AM

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  • HAL Id : tel-01928470, version 1

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Yu Xie. Pronostic factors on MRI in patients with acute ischemic stroke. Human health and pathology. Université de Lorraine, 2018. English. ⟨NNT : 2018LORR0143⟩. ⟨tel-01928470⟩

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