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Impact d’une carence périnatale en donneurs de méthyles sur l’ontogenèse et la plasticité des réseaux hypothalamiques et l’homéostasie énergétique

Abstract : The formation of the central nervous system occurs at an early stage of gestation and is followed by its maturation which continues after birth to ensure the proper functioning of neural circuits. Nutritional deficiency in methyl donors (B9/B12 vitamins) during this period leads to developmental abnormalities, growth retardation and persisting cognitive impairments. We investigated in a rat model of gestational deficiency the potential consequences on the development and plasticity of the hypothalamic networks involved in the regulation of eating behavior and energy homeostasis. We also tested whether maternal folate supplementation during the perinatal period, critical for brain maturation, may reduce the deficiency-associated growth retardation. The results showed that deficiency during the gestational period until weaning induces a disruption of the formation of the hypothalamic networks and a lack of integration of the peripheral metabolic signals as well as persisting abnormalities of the gastric mucosa with the activation of inflammation, apoptosis and oxidative stress. Late supplementation with folic acid (3 mg/kg/day) appeared to be beneficial and reversed the effects of deficiency.
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https://hal.univ-lorraine.fr/tel-02518282
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Submitted on : Wednesday, March 25, 2020 - 10:20:57 AM
Last modification on : Thursday, March 26, 2020 - 1:25:18 AM

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  • HAL Id : tel-02518282, version 1

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Lynda Saber Cherif. Impact d’une carence périnatale en donneurs de méthyles sur l’ontogenèse et la plasticité des réseaux hypothalamiques et l’homéostasie énergétique. Alimentation et Nutrition. Université de Lorraine, 2019. Français. ⟨NNT : 2019LORR0183⟩. ⟨tel-02518282⟩

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