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Conception et réalisation d'un biocapteur à matrice d’électrodes pour la caractérisation de milieux biologiques par spectroscopie d’impédance

Abstract : Knowledge of the electromagnetic properties of cells can provide early signals of disease or abnormal conditions in the human body for medical applications. In combination with microfluidic devices, impedance spectroscopy can be a powerful tool for sorting, analyzing, counting and discriminating cells. The main objective of this thesis is the characterization of isolated biological cells by measurement of unit-scale impedance spectroscopy and thus to be able to characterize them, in this thesis project we have done. The design and development of a coplanar electrode matrix biosensor are the second objective of this work, the idea being ultimately to be able to perform simultaneous measurements on several unit cells. The electrode matrix-shaped structure makes it possible to increase the number of cells measured as the number of electrodes increases. However, the electrode lead tracks can reduce the normalized impedance variation and thereby increase the difficulty in measuring cells between the electrodes. To analyze the effects of the connection tracks, propose improvements and observe the feasibility, we first used a simple 2x2 matrix. With this structure, we analyze analytically, by simulations and by experimental measurements, the influence of the connection tracks on the frequency band and on the standardized impedance variation. To reduce the effects of connection tracks, we have reduced their dimensions as well and we have used shown the advantage of using an insulator layer on the connection tracks.
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https://hal.univ-lorraine.fr/tel-02555956
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Submitted on : Monday, April 27, 2020 - 5:00:32 PM
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  • HAL Id : tel-02555956, version 1

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Arthur Luiz Alves de Araujo. Conception et réalisation d'un biocapteur à matrice d’électrodes pour la caractérisation de milieux biologiques par spectroscopie d’impédance. Electronique. Université de Lorraine, 2020. Français. ⟨NNT : 2020LORR0005⟩. ⟨tel-02555956⟩

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