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Contribution à l’étude de la réactivité de quelques accepteurs de Michael cycliques et applications

Abstract : This thesis focuses on the synthesis of some nitrogenous heterocycles from the same family of precursors: 1,4-diketones. These 1,4-diketones have been obtained either by a Nef reaction through the conversion of nitro compounds into ketones or by a Wittig reaction using various Wittig ylides and cyclohexanedione. These reaction intermediates were subsequently used for the synthesis of indole derivatives via a 1,2-addition reaction. We were also able to turn the selectivity of the reaction towards the synthesis of indolones from a 1,4-addition reaction. With hydrazine monohydrate, 1,4-diketones have also provided access to cinnolines in excellent yields.
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Submitted on : Monday, March 29, 2021 - 3:08:38 PM
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Dalel El-Marrouki. Contribution à l’étude de la réactivité de quelques accepteurs de Michael cycliques et applications. Chimie. Université de Lorraine; Université de Tunis El Manar, 2020. Français. ⟨NNT : 2020LORR0197⟩. ⟨tel-03184488⟩

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