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Theses

Caractérisation du phénotype hypercoagulable et de ses déterminants dans l’insuffisance cardiaque aiguë

Abstract : Acute heart failure (AHF) is a syndrome with an increasing prevalence and a high mortality whose management is challenging given the incomplete understanding of its pathophysiology. This doomed prognosis is partly influenced by thromboembolic events and is often the cause of death. The present study demonstrates a significant shift towards a prothrombotic biological profile at the acute phase of decompensated heart failure. Using a comprehensive exploration of the dynamics of thrombin generation and inhibition, we found an increased overall thrombin-generating capacity in AHF patients during hospital course. Both increased in circulating procoagulant microparticles and impairment in the downregulation of thrombin generation by the anticoagulant C protein pathway represent mechanisms contributing to this hypercoagulable state in AHF
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Theses
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http://docnum.univ-lorraine.fr/prive/DDOC_T_2016_0336_POPOVIC.pdf
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https://hal.univ-lorraine.fr/tel-03247840
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Submitted on : Thursday, June 3, 2021 - 11:41:48 AM
Last modification on : Friday, June 4, 2021 - 3:34:13 AM

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  • HAL Id : tel-03247840, version 1

Citation

Batric Popovic. Caractérisation du phénotype hypercoagulable et de ses déterminants dans l’insuffisance cardiaque aiguë. Sciences du Vivant [q-bio]. Université de Lorraine, 2016. Français. ⟨NNT : 2016LORR0336⟩. ⟨tel-03247840⟩

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