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Relations between aortic valve calcification and telomere lenght dynamics

Abstract : Aortic stenosis (AS), an age-related disease characterized by narrowing and obstruction of the aortic valve opening, is often related to progressive valve calcification. Mechanisms of valvular calcification involve several pathways influenced by aging. Some of these pathways might be induced by short telomeres, one of the hallmarks of aging. Currently, however, the role of telomere length (TL) in the onset and progression of AS remains unclear. To shed light on the implication of telomere dynamics in aortic valve calcification and aortic stenosis, we measured TL in aortic valves from patients with and without AS. We found that non-calcified areas of stenotic valves display shorter telomeres than corresponding valve areas of non-stenotic valves. Furthermore, we observed that within a calcified valve, calcified areas exhibit shorter telomeres than non-calcified areas, whereas telomerase activity was not detected in any of those. In addition, study of TL distributions (TLD) showed that, beside mean TL, calcification is associated with changes in TLD shape. Finally, preliminary results of a transcriptomic analysis revealed that TL in aortic valves might be involved in the regulation of gene expression. These results suggest that short telomeres in aortic valves may contribute to the onset and development of AS. In addition, a further decrease of TL in calcified areas seems to be an after effect of the calcification process. These findings may have long-term ramifications that will potentially allow identification of individuals at high risk for aortic valve stenosis during the aging process. For a better understanding of the involvement of telomere length in aortic valve calcification further mechanistic studies are required.
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Submitted on : Friday, June 18, 2021 - 2:45:53 PM
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  • HAL Id : tel-03264723, version 1

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Ilona Saraieva. Relations between aortic valve calcification and telomere lenght dynamics. Life Sciences [q-bio]. Université de Lorraine, 2020. English. ⟨NNT : 2020LORR0237⟩. ⟨tel-03264723⟩

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