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Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry

Abstract : The aim of this review is to provide a summary of the use of copper-catalyzed azide-alkyne cycloaddition (CuAAC) in the synthesis of porphyrin, chlorin and phthalocyanine derivatives for different types of therapeutic applications. The click reaction is a powerful and versatile tool for scientists working on the synthesis of various symmetrically and asymmetrically substituted tetrapyrrolic derivatives. For example, click chemistry is widely used for the elaboration of photosensitizer conjugates for photodynamic therapy applications. Other biological applications are also described.
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https://hal.univ-lorraine.fr/hal-01270989
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Submitted on : Monday, February 8, 2016 - 4:46:18 PM
Last modification on : Wednesday, August 24, 2022 - 3:26:28 PM

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Samir Acherar, Ludovic Colombeau, Céline Frochot, Régis Vanderesse. Synthesis of Porphyrin, Chlorin and Phthalocyanine Derivatives by Azide-Alkyne Click Chemistry. Current Medicinal Chemistry, 2015, 22 (28), pp.3217-3254. ⟨10.2174/0929867322666150716115832⟩. ⟨hal-01270989⟩

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