Synthesis and photophysical properties of the photoactivatable cationic porphyrin 5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide for anti-malaria PDT - Université de Lorraine Access content directly
Journal Articles Photochemical & Photobiological Sciences Year : 2015

Synthesis and photophysical properties of the photoactivatable cationic porphyrin 5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide for anti-malaria PDT

Abstract

This article describes a new synthetic method for obtaining three water soluble porphyrins. The more sophisticated porphyrin [5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphy rin tetraiodide], also named C12 porphyrin, was obtained through a three step methodology. The improvements, compared to syntheses described in the literature, mostly concern the purification procedures. The photophysical properties of the three porphyrins are described and the C12 porphyrin presents a very good O-1(2) yield compared to its chemical intermediates. This porphyrin seems to be a very promising candidate for PDT applications.
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hal-01270996 , version 1 (08-02-2016)

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Aurélie Stallivieri, Florent Le Guern, Régis Vanderesse, Esme Meledje, Giulio Jori, et al.. Synthesis and photophysical properties of the photoactivatable cationic porphyrin 5-(4-N-dodecylpyridyl)-10,15,20-tri(4-N-methylpyridyl)-21H,23H-porphyrin tetraiodide for anti-malaria PDT. Photochemical & Photobiological Sciences , 2015, 14 (7), pp.1290-1295. ⟨10.1039/c5pp00139k⟩. ⟨hal-01270996⟩
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