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Lipophilic phthalocyanines for their potential interest in photodynamic therapy: synthesis and photo-physical properties

Abstract : Several phthalocyanines with different peripheral substituents were prepared and characterized by MALDI-TOF, H-1 NMR, UV-vis, fluorescence, and singlet oxygen quantum yields and retention time in HPLC normal phase. Zinc was used as a central metal ion to increase the photodynamic therapy efficiency. Phthalonitrile or 4-nitro phthalonitriles were used as starting materials. The influence of lipophilicity on the photophysical and photochemical properties was evaluated.
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https://hal.univ-lorraine.fr/hal-01278786
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Submitted on : Wednesday, February 24, 2016 - 6:10:42 PM
Last modification on : Tuesday, March 30, 2021 - 3:24:36 AM

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Albert Moussaron, Philippe Arnoux, Régis Vanderesse, Estelle Sibille, Patrick Chaimbault, et al.. Lipophilic phthalocyanines for their potential interest in photodynamic therapy: synthesis and photo-physical properties. Tetrahedron, Elsevier, 2013, 69 (47), pp.10116-10122. ⟨10.1016/j.tet.2013.09.035⟩. ⟨hal-01278786⟩

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