Behavioral effects of neonatal lesions on the cerebellar system

Abstract : Several rodent models with spontaneous mutations causing cerebellar pathology are impaired in motor functions during the neonatal period, including Grid2(LC), Rora(sg), Dab1(scm), Girk2(wv), Lmx1a(dr-sst) Myo5a(dn), Inpp4a(wbl), and Cacna1a(rol) mice as well as shaker and dystonic rats. Deficits are also evident in murine null mutants such as Zic1, Fgfr1/FgFr2, and Xpa/Ercc8. Behavioral deficits are time-dependent following X-irradiated- or aspiration-induced lesions of the cerebellum in rats. In addition, motor functions are deficient after lesions in cerebellar-related pathways. As in animal subjects, sensorimotor disturbances have been described in children with cerebellar lesions. These results underline the importance of the cerebellum and its connections in the development of motor functions.
Type de document :
Article dans une revue
International Journal of Developmental Neuroscience, Elsevier, 2015, 43, pp.58 - 65. 〈http://www.sciencedirect.com/science/article/pii/S0736574815000556〉. 〈10.1016/j.ijdevneu.2015.04.007〉
Liste complète des métadonnées

https://hal.univ-lorraine.fr/hal-01482061
Contributeur : Simpa Ul <>
Soumis le : vendredi 3 mars 2017 - 11:15:38
Dernière modification le : mardi 5 juin 2018 - 10:14:34

Identifiants

Citation

Robert Lalonde, Catherine Strazielle. Behavioral effects of neonatal lesions on the cerebellar system. International Journal of Developmental Neuroscience, Elsevier, 2015, 43, pp.58 - 65. 〈http://www.sciencedirect.com/science/article/pii/S0736574815000556〉. 〈10.1016/j.ijdevneu.2015.04.007〉. 〈hal-01482061〉

Partager

Métriques

Consultations de la notice

83