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Herpes simplex virus type 1 hepatitis due to primary infection in a pancreas-kidney transplant recipient

Abstract : Herpes simplex Virus (HSV) hepatitis is a rare complication of HSV-1 primary infection, with a delayed diagnosis, affecting mainly immunocompromised patients. We describe a case of HSV-1 hepatitis after primary infection occurring in the postoperative days after a pancreas-kidney transplantation. The patient presented with an unusual evolution of a persistent severe hepatitis associated with a persistent viremia (Quantitative Polymerase Chain Reaction) despite an adequate intravenous (iv) antiviral treatment. Abdominal computed tomography scan showed a miliary hepatitis. The diagnosis of HSV-1 hepatitis was confirmed by immuno-chemistry on liver biopsy. The donor was negative for anti-HSV antibodies, excluding contamination by the graft. This case report emphasizes a rather seldom risk of care-associated viral infections, predominantly in immunocompromised patients.
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https://hal.univ-lorraine.fr/hal-01489933
Contributor : Simpa Ul <>
Submitted on : Tuesday, March 14, 2017 - 4:39:45 PM
Last modification on : Thursday, April 25, 2019 - 3:14:05 PM

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J. Feugeas, S. Mory, H. Jeulin, A. Velay, J-P. Pertek, et al.. Herpes simplex virus type 1 hepatitis due to primary infection in a pancreas-kidney transplant recipient. Journal of Clinical Virology, Elsevier, 2016, 80, pp.57 - 59. ⟨10.1016/j.jcv.2016.04.015⟩. ⟨hal-01489933⟩

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