HAL will be down for maintenance from Friday, June 10 at 4pm through Monday, June 13 at 9am. More information
Skip to Main content Skip to Navigation
Journal articles

Biocompatible nanodispersions as delivery systems of food additives: A structural study

Abstract : Nanodispersions based on food grade biocompatible materials were developed and structurally characterized to be used as carriers of bioactive compounds with specific nutritional value. The main idea was to formulate concentrated solutions of specific food components at the nanoscale to be consumed either on their own or as integrating parts of classic foods, upon aqueous dilution. For this purpose microemulsions consisting of (R)-(+)-limonene/ethanol/Tween 40/water/propylene glycol were formulated in the presence and in the absence of squalene, gallic acid and octyl gallate. The limits of the single-phase region as described by pseudo-ternary phase diagrams were related to the nature of the food additive. The more extended monophasic region was obtained when octyl gallate was added in the system. Interfacial properties of the microemulsions were studied by electron paramagnetic resonance (EPR) spectroscopy employing the nitroxide spin probe 5-doxylstearic acid (5-DSA). In general guest molecules decreased the flexibility of the surfactant monolayer as manifested from the calculation of rotational correlation time (T-R) and order parameter S of 5-DSA. Particle size measurements were performed using dynamic light scattering (DLS) and oil droplet diameters in the range of 11.7 to 17.4 nm were observed. The addition of squalene resulted in the formulation of larger oily droplets whereas octyl gallate formed smaller ones. Finally SAXS experiments provided qualitative information of o/w microemulsions showing squalene solubilization in the dispersed oily phase, octyl gallate localization on the membrane and gallic acid solubilization in the continuous aqueous phase.
Document type :
Journal articles
Complete list of metadata

Contributor : Srsmc Ul Connect in order to contact the contributor
Submitted on : Wednesday, March 22, 2017 - 1:53:03 PM
Last modification on : Monday, December 13, 2021 - 1:14:06 PM




Argyro Kalaitzaki, Melanie Emo, Marie José Stebe, Aristotelis Xenakis, Vassiliki Papadimitriou. Biocompatible nanodispersions as delivery systems of food additives: A structural study. Food Research International, Elsevier, 2013, 54 (2), pp.1448-1454. ⟨10.1016/j.foodres.2013.08.010⟩. ⟨hal-01493933⟩



Record views