Synthesis of amphiphilic, chalcogen-based redox modulators with in vitro cytotoxic activity against cancer cells, macrophages and microbes
Peng Du
(1)
,
Uma M. Viswanathan
(1, 2)
,
Khairan Khairan
(1, 3)
,
Tomislav Buric
(1)
,
Nathaniel E. B. Saidu
(1)
,
Zhanjie Xu
(4)
,
Benjamin Hanf
(1)
,
Inga Bazukyan
(2)
,
Armen Trchounian
(2)
,
Frank Hannemann
(1)
,
Ingolf Bernhardt
(1)
,
Torsten Burkholz
(1)
,
Britta Diesel
(1)
,
Alexandra K. Kiemer
(1)
,
Karl-Herbert Schaefer
(1)
,
Mathias Montenarh
(1)
,
Gilbert Kirsch
(4)
,
Claus Jacob
(1)
Peng Du
- Function : Author
- PersonId : 781665
- ORCID : 0000-0002-7277-4289
Zhanjie Xu
- Function : Author
- PersonId : 781645
- IdRef : 18105938X
Abstract
Several amphiphilic, chalcogen-based redox modulators have been synthesized which exhibit a widespread, yet in some instances also selective, biological activity which is most likely based on their ability to modulate the intracellular redox balance and to interact with cellular membranes and specific proteins.