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Photofunctional Nanomodulators for Bioexcitation

Abstract : A single organism comprises diverse types of cells. To acquire a detailed understanding of the biological functions of each cell, comprehensive control and analysis of homeostatic processes at the single-cell level are required. In this study, we develop a new type of light-driven nanomodulator comprising dye-functionalized carbon nanohorns (CNHs) that generate heat and reactive oxygen species under biologically transparent near-infrared (NIR) laser irradiation. By exploiting the physicochemical properties of the nanohorns, cellular calcium ion flux and membrane currents were successfully controlled at the single-cell level. In addition, the nanomodulator allows a remote bioexcitation of tissues during NIR laser exposure making this system a powerful tool for single-cell analyses and innovative cell therapies.
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Submitted on : Thursday, March 23, 2017 - 4:48:49 PM
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Eijiro Miyako, Julie Russier, Matteo Mauro, Cristina Cebrian, Hiromu Yawo, et al.. Photofunctional Nanomodulators for Bioexcitation. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2014, 53 (48), pp.13121 - 13125. ⟨10.1002/anie.201407169⟩. ⟨hal-01494605⟩



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