C-Functionalized chiral dioxocyclam and cyclam derivatives with 1,2,3-triazole units: synthesis, complexation properties and crystal structures of copper(II) complexes - Université de Lorraine
Article Dans Une Revue New Journal of Chemistry Année : 2016

C-Functionalized chiral dioxocyclam and cyclam derivatives with 1,2,3-triazole units: synthesis, complexation properties and crystal structures of copper(II) complexes

Résumé

New C-functionalized syn- and anti-dioxocyclam and cyclam derivatives with 1,2,3-triazole units attached to carbon atoms within the skeleton were designed as valuable bifunctional chelating agents for applications in nuclear medicine. These macrocyclic chelators were prepared via a multi-step sequence involving alpha- and beta-amino acids, and their copper(II) complexation properties were evaluated. A solution structure in which the triazoles are in axially coordinating positions was proposed for the [Cu(anti-27)](2+) complex. Promising results have been obtained regarding the complexation kinetics (<10 s) and the pseudo-first order half-life for acid-assisted dissociation (t(1/2) = 3.21 d, 5 M HCl, 50 degrees C).

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Chimie
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Dates et versions

hal-01495195 , version 1 (24-03-2017)

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Citer

A. -S. Fetten, N. Petry, B. Henry, Nadia Pellegrini-Moïse, Katalin Selmeczi. C-Functionalized chiral dioxocyclam and cyclam derivatives with 1,2,3-triazole units: synthesis, complexation properties and crystal structures of copper(II) complexes. New Journal of Chemistry, 2016, 40 (2), pp.1507-1520. ⟨10.1039/c5nj01927c⟩. ⟨hal-01495195⟩
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