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Is bismuth subsalicylate an effective nontoxic catalyst for plga synthesis?

Abstract : Poly(d,l-lactide-co-glycolide) (PLGA) copolyesters are commonly used in biomedical applications. Researches were carried out on nontoxic or low-toxic catalysts that are enough efficient to provide short polymerization times, adequate microstructure chains and similar properties than the commercial PLGA materials. In this study, PLGA were synthesized by ring-opening copolymerization (ROP) using three different catalysts. Stannous octoate is the first catalyst we used, as it is very efficient, even its toxicity is still on debate. Two others low-toxic catalysts [zinc lactate and bismuth subsalicylate (BiSS)] were also evaluated. The comparison of these ROP was realized in terms of kinetics and control of the polymerization. Then, the influence of the catalyst on the PLGA microstructure chains is reported. Finally, abiotic hydrolytic degradation rate is studied. Results described in this article show that BiSS is one very attractive catalyst to produce low toxic PLGA for biomedical applications.
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Charlotte Duval, Cécile Nouvel, Jean-Luc Six. Is bismuth subsalicylate an effective nontoxic catalyst for plga synthesis?. Journal of Polymer Science Part A: Polymer Chemistry, Wiley, 2014, 52 (8), pp.1130 - 1138. ⟨10.1002/pola.27096⟩. ⟨hal-01498309⟩



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