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Triumfettamide B, a New Ceramide from the Twigs of Triumfetta rhomboidea

Abstract : A new ceramide (1) along with lupeol (2) and a mixture of β-sitosterol and stigmasterol, oleanolic acid (4), maslinic acid (5), β-sitosterol glucopyranoside (6), and trans-tiliroside (7) were isolated from Triumfetta rhomboidea (Tiliaceae). Their structures were determined on the basis of spectroscopic methods and mass spectrometry analysis, as well as by comparison of their physical and spectral data with those reported in the literature. The cytotoxic activity of crude extract, fractions, and some compounds were evaluated against human fibrosarcoma cancer cell line HT1080 using flow cytometry. The ethyl acetate fraction showed weak activity while the crude extract and the hexane and n-butanol fractions presented less than 50% of cell growth inhibition.
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https://hal.univ-lorraine.fr/hal-01524714
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Submitted on : Thursday, May 18, 2017 - 4:57:03 PM
Last modification on : Saturday, February 27, 2021 - 3:05:43 AM

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Abdou Tchoukoua, Sandjo Louis Pergaud, Felix Keumedjio, Tchaleu Ngadjui Bonaventure, Gilbert Kirsch. Triumfettamide B, a New Ceramide from the Twigs of Triumfetta rhomboidea. Chemistry of Natural Compounds, Springer Verlag, 2013, 49 (5), pp.811-814. ⟨hal-01524714⟩

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