20-nm-sized mesoporous silica nanoparticles with porphyrin photosensitizers for in vitro photodynamic therapy

Abstract : We report the synthesis of 20-nm-sized mesoporous silica nanoparticles encapsulating three different porphyrin photosensitizers (PS). Synthesized by the sol–gel method, in the presence of cetyltrimethylammonium bromide surfactant and tetraorthosilicate as silica source, we developed those nanoparticles with the aim of treating cancer cells using photodynamic therapy. The colloidal stability, due to the PEG-silane chain grafted on the surface, was demonstrated at 37 C in cell culture medium. Then, nanoparticles were functionalized by silylated squarate mannose and used in MCF-7 breast cancer cells for one-photon therapy. Promising results were obtained after 5 h of incubation.
Type de document :
Article dans une revue
Journal of Sol-Gel Science and Technology, Springer Verlag, 2016, 79 (3), pp.447-456. 〈10.1007/s10971-016-3991-6〉
Liste complète des métadonnées

Littérature citée [54 références]  Voir  Masquer  Télécharger

https://hal.univ-lorraine.fr/hal-01569372
Contributeur : Philippe Arnoux <>
Soumis le : jeudi 14 décembre 2017 - 17:16:39
Dernière modification le : vendredi 16 février 2018 - 11:08:02
Document(s) archivé(s) le : jeudi 15 mars 2018 - 12:23:01

Fichier

09 Mauriello et al.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Citation

Chiara Mauriello Jimenez, Yolanda Galàn Rubio, Valentin Saunier, David Warther, Vanja Stojanovic, et al.. 20-nm-sized mesoporous silica nanoparticles with porphyrin photosensitizers for in vitro photodynamic therapy. Journal of Sol-Gel Science and Technology, Springer Verlag, 2016, 79 (3), pp.447-456. 〈10.1007/s10971-016-3991-6〉. 〈hal-01569372〉

Partager

Métriques

Consultations de la notice

308

Téléchargements de fichiers

48