Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age

Abstract : Lactational exposure to low levels of the sum of the six indicator polychlorinated biphenyls (Σ6 NDL-PCBs, 10 ng/kg/day) is known to lead to persistent anxious behavior in young and adult offspring mice at postnatal days 40 and 160, respectively. At more advanced life stages, we evaluated the effects on the mouse brain of neuronal stress induced by the synaptotoxic amyloid-beta (Aβ) peptide. Perinatal exposure of lactating mice to Σ6 NDL-PCBs did not affect short-term memory performances of their offspring male mice aged 14 months as compared to control PCB-naive mice. However, following intracerebroventricular injection of soluble Aβ oligomers, significant impairments in long-term memory were detected in the mice that had been lactationally treated with Σ6 NDL-PCBs. In addition, immunoblot analyses of the synaptosomal fraction of hippocampal tissues from treated mice revealed a lower expression of the synaptic proteins synaptophysin and PSD-95. Though preliminary, our findings suggest for the first time that early exposure to low levels of NDL-PCBs induce late neuronal vulnerability to amyloid stress. Additional experiments are needed to confirm whether early environmental influences are involved in the etiology of brain aging and cognitive decline.
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NeuroToxicology, Elsevier, 2016, 53, pp.314 - 320. 〈10.1016/j.neuro.2015.10.003〉
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Soumis le : lundi 21 août 2017 - 14:30:05
Dernière modification le : lundi 19 mars 2018 - 15:08:43

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Arpine Ardzivian Elnar, Ahmad Allouche, Frédéric Desor, Frances T. Yen, Rachid Soulimani, et al.. Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age. NeuroToxicology, Elsevier, 2016, 53, pp.314 - 320. 〈10.1016/j.neuro.2015.10.003〉. 〈hal-01575678〉

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