Skip to Main content Skip to Navigation
Journal articles

In Vitro and In Vivo Anti-Melanoma Effects of Pituranthos tortuosus Essential Oil Via Inhibition of FAK and Src Activities

Abstract : A large number of plants used in traditional medicines have been shown to possess antitumor activities. The aims of this study were to evaluate any anticancer effect of the essential oil (EO) extracted from P. tortuosus against B16F10 melanoma cancer cells in vitro as well as in vivo. In vitro, EO was shown to induce apoptosis and to inhibit migration and invasion processes. Further investigation revealed that EO decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of FAK, Src, ERK, p130Cas and paxillin. Moreover, EO treatment decreased the expression level of p190RhoGAP, and Grb2, which impair cell migration and actin assembly. Mice bearing the melanoma cells were used to confirm any in vivo effectiveness of the EO as an anti-tumor promoting agent. In mice dosed with 100 mg EO/kg/d (for 27 days), tumor weight was inhibited by 98% compared to that in mice that did not receive the product. In conclusion, these data suggested to us that an EO of P. tortuosus could evolve to be a potential medicinal resource for use in the treatment of cancers.
Document type :
Journal articles
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-01598421
Contributor : Lermab Ul <>
Submitted on : Friday, September 29, 2017 - 3:32:07 PM
Last modification on : Thursday, June 6, 2019 - 2:50:06 PM

Links full text

Identifiers

Citation

Mounira Krifa, Salah Edin El Meshri, Nawel Bentouati, Antonio Pizzi, Emilie Sick, et al.. In Vitro and In Vivo Anti-Melanoma Effects of Pituranthos tortuosus Essential Oil Via Inhibition of FAK and Src Activities. Journal of Cellular Biochemistry, Wiley, 2016, 117 (5), pp.1167-1175. ⟨10.1002/jcb.25400⟩. ⟨hal-01598421⟩

Share

Metrics

Record views

90