Skip to Main content Skip to Navigation
Journal articles

A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast

Abstract : A mutated allele of the essential gene TAH18 was previously identified in our laboratory in a genetic screen for new proteins interacting with the DNA polymerase delta in yeast [1]. The present work shows that Tah18 plays a role in response to oxidative stress. After exposure to lethal doses of H 2 O 2 , GFP-Tah18 relocalizes to the mitochondria and controls mitochondria integrity and cell death. Dre2, an essential Fe/S cluster protein and homologue of human anti-apoptotic Ciapin1, was identified as a molecular partner of Tah18 in the absence of stress. Moreover, Ciapin1 is able to replace yeast Dre2 in vivo and physically interacts with Tah18. Our results are in favour of an oxidative stress-induced cell death in yeast that involves mitochondria and is controlled by the newly identified Dre2-Tah18 complex.
Complete list of metadata

Cited literature [56 references]  Display  Hide  Download

https://hal.univ-lorraine.fr/hal-01625408
Contributor : Nicolas Soler <>
Submitted on : Friday, October 27, 2017 - 3:14:08 PM
Last modification on : Tuesday, November 24, 2020 - 10:50:02 AM
Long-term archiving on: : Sunday, January 28, 2018 - 3:21:01 PM

File

A newly identified essential c...
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Laurence Vernis, Céline Facca, Emmanuelle Delagoutte, Nicolas Soler, Roland Chanet, et al.. A Newly Identified Essential Complex, Dre2-Tah18, Controls Mitochondria Integrity and Cell Death after Oxidative Stress in Yeast. PLoS ONE, Public Library of Science, 2009, 4 (2), pp.e4376. ⟨10.1371/journal.pone.0004376⟩. ⟨hal-01625408⟩

Share

Metrics

Record views

268

Files downloads

192