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Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease

Abstract : Therapeutic monoclonal anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) antibodies are associated with immune-mediated enterocolitis. The aim of this study was to provide a detailed description of this entity. We included patients with endoscopic signs of inflammation after anti-CTLA-4 infusions for cancer treatment. Other causes of enterocolitis were excluded. Clinical, biological and endoscopic data were recorded. A single pathologist reviewed endoscopic biopsies and colectomy specimens from 27 patients. Patients with and without enterocolitis after ipilimumab-treated melanoma were compared, to identify clinical factors associated with enterocolitis. Thirty-nine patients with anti-CTLA-4 enterocolitis were included (ipilimumab
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https://hal.univ-lorraine.fr/hal-01659102
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Submitted on : Friday, December 8, 2017 - 10:08:31 AM
Last modification on : Thursday, December 10, 2020 - 3:44:06 AM

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L. Marthey, C. Mateus, C. Mussini, M. Nachury, S. Nancey, et al.. Cancer Immunotherapy with Anti-CTLA-4 Monoclonal Antibodies Induces an Inflammatory Bowel Disease. Journal of Crohn's and Colitis, Elsevier - Oxford University Press, 2016, 10 (4), pp.395-401. ⟨10.1093/ecco-jcc/jjv227⟩. ⟨hal-01659102⟩

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