Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm

Lutske Lodewijk 1 Wouter P. Kluijfhout 1 Jakob W. Kist 1 Inge Stegeman 1 John T. M. Plukker 2 Els J. Nieveen Dijkum 3 H. Jaap Bonjer 4 Nicole D. Bouvy 5 Abbey Schepers 6 Johannes H. W. Wilt 7 Romana T. Netea-Maier 7 Jos A. Hage 8 Jacobus W. A. Burger 9 Gavin Ho 10 Wayne S. Lee 10 Wen T. Shen 10 Anna Aronova 11 Rasa Zarnegar 11 Cassandre Benay 12 Elliot J. Mitmaker 12 Mark S. Sywak 13 Ahmad M. Aniss 13 Schelto Kruijff 13 Benjamin James 14 Raymon H. Grogan 14 Laurent Brunaud 15, 16 Guillaume Hoch 17 Chiara Pandolfi 18 Daniel T. Ruan 18 Michael D. Jones 19 Marlon A. Guerrero 19 Gerlof D. Valk 1 Inne H. M. Borel Rinkes 1 Menno R. Vriens 1
Abstract : Purpose Traditionally, total thyroidectomy has been advocated for patients with tumors larger than 1 cm. However, according to the ATA and NCCN guidelines (2015, USA), patients with tumors up to 4 cm are now eligible for lobectomy. A rationale for adhering to total thyroidectomy might be the presence of contralateral carcinomas. The purpose of this study was to describe the characteristics of contralateral carcinomas in patients with differentiated thyroid cancer (DTC) larger than 1 cm. Methods A retrospective study was performed including patients from 17 centers in 5 countries. Adults diagnosed with DTC stage T1b-T3 N0-1a M0 who all underwent a total thyroidectomy were included. The primary endpoint was the presence of a contralateral carcinoma. Results A total of 1313 patients were included, of whom 426 (32 %) had a contralateral carcinoma. The contralateral carcinomas consisted of 288 (67 %) papillary thyroid carcinomas (PTC), 124 (30 %) follicular variant of a papillary thyroid carcinoma (FvPTC), 5 (1 %) follicular thyroid carcinomas (FTC), and 3 (1 %) Hurthle cell carcinomas (HTC). Ipsilateral multifocality was strongly associated with the presence of contralateral carcinomas (OR 2.62). Of all contralateral carcinomas, 82 % were <= 10 mm and of those 99 % were PTC or FvPTC. Even if the primary tumor was a FTC or HTC, the contralateral carcinoma was (Fv) PTC in 92 % of cases. Conclusions This international multicenter study performed on patients with DTC larger than 1 cm shows that contralateral carcinomas occur in one third of patients and, independently of primary tumor subtype, predominantly consist of microPTC.
Type de document :
Article dans une revue
Langenbeck's Archives of Surgery, Springer Verlag, 2016, 401 (3), pp.365-373. 〈10.1007/s00423-016-1393-4〉
Liste complète des métadonnées

https://hal.univ-lorraine.fr/hal-01659120
Contributeur : Ngere Ul <>
Soumis le : vendredi 8 décembre 2017 - 10:09:12
Dernière modification le : mardi 25 septembre 2018 - 10:32:02

Lien texte intégral

Identifiants

Collections

Citation

Lutske Lodewijk, Wouter P. Kluijfhout, Jakob W. Kist, Inge Stegeman, John T. M. Plukker, et al.. Characteristics of contralateral carcinomas in patients with differentiated thyroid cancer larger than 1 cm. Langenbeck's Archives of Surgery, Springer Verlag, 2016, 401 (3), pp.365-373. 〈10.1007/s00423-016-1393-4〉. 〈hal-01659120〉

Partager

Métriques

Consultations de la notice

33