Synthesis of mono-, di- and triporphyrin building blocks by click chemistry for photodynamic therapy application - Université de Lorraine Access content directly
Journal Articles Tetrahedron Year : 2017

Synthesis of mono-, di- and triporphyrin building blocks by click chemistry for photodynamic therapy application

Abstract

In the present work, we describe a successful strategy centered on the use of click chemistry to synthesize mono-, di-and triporphyrin building blocks named [ZnTPP] 1 , [ZnTPP] 2 and [ZnTPP] 3. The number of photosensitizers (ZnTPP unit) coupled to the building blocks does not seem to dramatically modify the photophysical properties of the photosensitizer in terms of fluorescence and singlet oxygen formation, quantum yields and lifetime. These building blocks, obtained in high yield, could be combined with a targeting agent (vector) to create new photosensitizer-vector conjugates to investigate the optimum ratio of photosensitizer needed for maximum photodynamic therapy efficiency.
Fichier principal
Vignette du fichier
14 Mohd Gazzali-Tetrahedron-73 (2017).pdf (456.52 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Loading...

Dates and versions

hal-01663126 , version 1 (14-12-2017)

Identifiers

Cite

Amirah Mohd Gazzali, Ludovic Colombeau, Philippe Arnoux, Habibah A. Wahab, Céline Frochot, et al.. Synthesis of mono-, di- and triporphyrin building blocks by click chemistry for photodynamic therapy application. Tetrahedron, 2017, 73 (5), pp.532-541. ⟨10.1016/j.tet.2016.12.037⟩. ⟨hal-01663126⟩
78 View
413 Download

Altmetric

Share

Gmail Facebook X LinkedIn More