Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I 131 during Adolescence and Young Adulthood - Université de Lorraine Accéder directement au contenu
Article Dans Une Revue International Journal of Endocrinology Année : 2016

Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I 131 during Adolescence and Young Adulthood

Résumé

Differentiated thyroid cancer (DTC) is rare and confers good prognosis. Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods. Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I-131 before age of 25 years. Results. Forty-five of 61 patients (74%) responded to the survey. Cumulative I-131 activity was <= 3.85 GBq in 18 subjects and >3.85 GBq in 27 subjects. Mean time from diagnosis was 7.6 +/- 5.2 years for the group <= 3.85 GBq versus 16.9 +/- 11.6 years for the group >3.85 GBq (P < 0.05). No significant alteration in long-term HRQoL and global self-esteem was observed. Thirty pregnancies after I-131 were noted in patients from the group >3.85 GBq and 10 in patients from the group <= 3.85 GBq. Frequency of miscarriages was of 17% (group >3.85 GBq) and 10% (group <= 3.85 GBq) with 9 and 24 live births, respectively. No congenital malformations or first year mortality was noted. Conclusion. Long-term HRQoL, global self-esteem, and pregnancy outcomes are not affected in young female survivors of DTC.
Fichier principal
Vignette du fichier
7586482.pdf (1.34 Mo) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-01663658 , version 1 (14-12-2017)

Licence

Identifiants

Citer

Melanie Metallo, Lelia Groza, Laurent Brunaud, Marc Klein, Georges Weryha, et al.. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I 131 during Adolescence and Young Adulthood. International Journal of Endocrinology, 2016, 2016, pp.7586482. ⟨10.1155/2016/7586482⟩. ⟨hal-01663658⟩
53 Consultations
102 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More