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Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I 131 during Adolescence and Young Adulthood

Abstract : Differentiated thyroid cancer (DTC) is rare and confers good prognosis. Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods. Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I-131 before age of 25 years. Results. Forty-five of 61 patients (74%) responded to the survey. Cumulative I-131 activity was <= 3.85 GBq in 18 subjects and >3.85 GBq in 27 subjects. Mean time from diagnosis was 7.6 +/- 5.2 years for the group <= 3.85 GBq versus 16.9 +/- 11.6 years for the group >3.85 GBq (P < 0.05). No significant alteration in long-term HRQoL and global self-esteem was observed. Thirty pregnancies after I-131 were noted in patients from the group >3.85 GBq and 10 in patients from the group <= 3.85 GBq. Frequency of miscarriages was of 17% (group >3.85 GBq) and 10% (group <= 3.85 GBq) with 9 and 24 live births, respectively. No congenital malformations or first year mortality was noted. Conclusion. Long-term HRQoL, global self-esteem, and pregnancy outcomes are not affected in young female survivors of DTC.
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Melanie Metallo, Lelia Groza, Laurent Brunaud, Marc Klein, Georges Weryha, et al.. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I 131 during Adolescence and Young Adulthood. International Journal of Endocrinology, Hindawi Publishing Corporation, 2016, 2016, pp.7586482. ⟨10.1155/2016/7586482⟩. ⟨hal-01663658⟩

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