Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I 131 during Adolescence and Young Adulthood
CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy (Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEX
Hôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 Nancy
Hôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-Nancy
Maternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy - France)
Abstract : Differentiated thyroid cancer (DTC) is rare and confers good prognosis. Long-term health related quality of life (HRQoL) and pregnancy outcomes are not well known in subjects treated during adolescence and young adulthood. Methods. Cross-sectional analysis of HRQoL and global self-esteem, using SF-36 and ISP-25 surveys, and of pregnancy outcomes in female survivors of DTC treated by total thyroidectomy and I-131 before age of 25 years. Results. Forty-five of 61 patients (74%) responded to the survey. Cumulative I-131 activity was <= 3.85 GBq in 18 subjects and >3.85 GBq in 27 subjects. Mean time from diagnosis was 7.6 +/- 5.2 years for the group <= 3.85 GBq versus 16.9 +/- 11.6 years for the group >3.85 GBq (P < 0.05). No significant alteration in long-term HRQoL and global self-esteem was observed. Thirty pregnancies after I-131 were noted in patients from the group >3.85 GBq and 10 in patients from the group <= 3.85 GBq. Frequency of miscarriages was of 17% (group >3.85 GBq) and 10% (group <= 3.85 GBq) with 9 and 24 live births, respectively. No congenital malformations or first year mortality was noted. Conclusion. Long-term HRQoL, global self-esteem, and pregnancy outcomes are not affected in young female survivors of DTC.
https://hal.univ-lorraine.fr/hal-01663658 Contributor : Ngere UlConnect in order to contact the contributor Submitted on : Thursday, December 14, 2017 - 10:42:31 AM Last modification on : Tuesday, October 13, 2020 - 10:47:28 AM
Melanie Metallo, Lelia Groza, Laurent Brunaud, Marc Klein, Georges Weryha, et al.. Long-Term Quality of Life and Pregnancy Outcomes of Differentiated Thyroid Cancer Survivors Treated by Total Thyroidectomy and I 131 during Adolescence and Young Adulthood. International Journal of Endocrinology, Hindawi Publishing Corporation, 2016, 2016, pp.7586482. ⟨10.1155/2016/7586482⟩. ⟨hal-01663658⟩