Skip to Main content Skip to Navigation
Journal articles

Mechanisms behind efficacy of tumor necrosis factor inhibitors in inflammatory bowel diseases

Abstract : Biological treatment with tumor necrosis factor (TNF) inhibitors is successful in the management of inflammatory bowel disease (IBD). All TNF inhibitors antagonize the pro-inflammatory cytokine TNF-alpha but with varying efficacies in IBD. The variations in efficacy probably are caused by structural differences between the agents that affect their mechanisms of action and pharmacokinetic properties. Several mechanisms have been proposed, such as modulation of the expression of pro-inflammatory mediators and a reduction in the number of activated immune cells. However, it seems that clinical efficacy is the result of a number of different mechanisms and that binding of transmembrane TNF by TNF inhibitors. Knowledge of the mechanisms of action has been obtained mainly through the use of in vitro assays that may differ significantly from the situation in vivo. This review discusses the available data on TNF inhibitors in order to identify mechanisms of importance for their efficacy in IBD. Thus, a better understanding of the mechanistic basis for clinical efficacy can lead to a more rational use of TNF inhibitors in the management of IBD.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-lorraine.fr/hal-01664661
Contributor : Ngere Ul <>
Submitted on : Friday, December 15, 2017 - 9:53:44 AM
Last modification on : Tuesday, October 13, 2020 - 10:46:35 AM

Identifiers

Collections

Citation

Caroline Meyer Olesen, Mehmet Coskun, Laurent Peyrin-Biroulet, Ole Haagen Nielsen. Mechanisms behind efficacy of tumor necrosis factor inhibitors in inflammatory bowel diseases. Alimentary Pharmacology & Therapeutics (Suppl), 2016, 159, pp.110 - 119. ⟨10.1016/j.pharmthera.2016.01.001⟩. ⟨hal-01664661⟩

Share

Metrics

Record views

115