Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study

Sheraz Markar 1 Caroline Gronnier 2, 3 Arnaud Pasquer 4 Alain Duhamel 5, 6 Hélène Beal 5, 6 Jérémie Thereaux 7 Johan Gagnière 8 Gil Lebreton 9, 10 Cécile Brigand 11 Bernard Meunier 12 Denis Collet 13 Christophe Mariette 2 Abdennahceur Dhahri 14 Delphine Lignier Cyril Cossé Marc Regimbeau Magalie Cabau 15 Jacques Jougon Bogdan Badic 7 Patrick Lozach Pierre Bail 16 Serge Cappeliez Issam El Nakadi Arnaud Alves Renaud Flamein 17 Denis Pezet 8 Federica Pipitone Bogdan Stan-Iuga 18 Nicolas Contival Eric Pappalardo Simon Msika 19 Styliani Mantziari Nicolas Demartines Flora Hec Marguerite Vanderbeken Williams Tessier Nicolas Briez 20 Fabien Fredon Alain Gainant 21 Muriel Mathonnet 22, 21 Marc Bigourdan Salim Mezoughi Christian Ducerf 23 Jacques Baulieux Jean-Yves Mabrut 24 Oussama Baraket Gilles Poncet 25 Mustapha Adam 26 Delphine Vaudoyer Peggy Jourdan Enfer Laurent Villeneuve 27 Olivier Glehen 28 Thibault Coste Michel Fabre 29 Frédéric Marchal 30 Romain Frisoni Ahmet Ayav 31 Laurent Brunaud 32 Laurent Bresler 31, 32 Charlotte Cohen 33 Olivier Aze Nicolas Venissac 34 Daniel Pop 35 Jerôme Mouroux 36 Ion Donici Michel Prudhomme 37 Emanuele Felli Stéphanie Lisunfui Marie Seman Gaelle Godiris Petit 38 Mehdi Karoui 39 Christophe Trésallet 40 Fabrice Menegaux 40 Jean-Christophe Vaillant 41 Laurent Hannoun 42 Brice Malgras Denis Lantuas Karine Pautrat 43 Marc Pocard 44 Patrice Valleur 45 Najim Chafai 46 Pierre Balladur 47 Magalie Lefrancois 46 Yann Parc 46 François Paye 46 Emmanuel Tiret 46 Marius Nedelcu 48 Letizia Laface Thierry Perniceni 49 Brice Gayet 50 Alexandre Filipello Jack Porcheron 51 Olivier Tiffet Noémie Kamlet Rodrigue Chemaly Amandine Klipfel Patrick Pessaux 52 Serge Rohr 53 Nicolas Carrère 54 Chiara Da Re Frederic Dumont 55 Diane Goéré 56 Dominique Elias 57 Claude Bertrand 58
38 Lab-STICC_UBS_CID_DECIDE
Lab-STICC - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance (UMR 3192), Lab-STICC - Laboratoire des sciences et techniques de l'information, de la communication et de la connaissance
Abstract : Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy. Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics. Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes. Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.
Type de document :
Article dans une revue
European Journal of Cancer, Elsevier, 2016, 56, pp.59-68. 〈10.1016/j.ejca.2015.11.024〉
Liste complète des métadonnées

https://hal.univ-lorraine.fr/hal-01666517
Contributeur : Ngere Ul <>
Soumis le : lundi 18 décembre 2017 - 14:41:45
Dernière modification le : vendredi 8 juin 2018 - 14:50:26

Identifiants

Citation

Sheraz Markar, Caroline Gronnier, Arnaud Pasquer, Alain Duhamel, Hélène Beal, et al.. Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study. European Journal of Cancer, Elsevier, 2016, 56, pp.59-68. 〈10.1016/j.ejca.2015.11.024〉. 〈hal-01666517〉

Partager

Métriques

Consultations de la notice

721