Correlation of SUV-derived indices with tumoral aggressiveness of gliomas in static 18F-FDOPA PET

Abstract : PURPOSE: Glioma grading is necessary for prognostic evaluation and optimal treatment decisions. The aims of this study were to establish whether a correlation between F-FDOPA uptake with tumor grade was observed and to determine which of the SUV-derived indices was the best correlated. PATIENTS AND METHODS: Thirty-one patients were retrospectively included (mean [SD] age, 36.8 [12.1] years) including 21 proven low-grade tumors due to histology, imaging, and clinical follow-up and 10 histologically proven high-grade tumors. Static PET acquisitions were postreconstructed between the 10th and 30th minute after injection of F-FDOPA. Regions of interest of 20 mm were applied to tumors, and isocontoured volumes were defined at levels of 50% and 80% of the peak intensity voxel. Background was quantified with 30-mm-diameter regions of interest on contralateral striatum and centrum semioval. Tumoral uptake was evaluated with the following SUV-derived indices: SUVmax, SUVmean, SUVmax, and SUVmean of isocontoured volume, tumor/striatum ratio (T/S), and tumor/normal brain ratio (T/N). RESULTS: All the SUV-derived indices tested were significantly correlated with tumor grade, considering low-grade and high-grade groups (P < 0.05), except for the SUVmean 50%. The 2 best-correlated indices were SUVmean T/N and SUVmean T/S, with correlation coefficients of 0.561 and 0.522, respectively. Receiver operating characteristic analysis defined optimal thresholds of 1.33 and 1 for sensitivity and specificity of 71% and 100% and 67% and 100%, respectively. CONCLUSIONS: F-FDOPA PET SUV-derived indices are routinely available information that enables accurate discrimination of low-grade and high-grade gliomas. The best-correlated indices were SUVmean T/N and SUVmean T/S with thresholds of 1.33 and 1.
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Clinical Nuclear Medicine, Lippincott, Williams & Wilkins, 2015, 40 (9), pp.e429-e435. 〈10.1097/RLU.0000000000000897〉
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Soumis le : mercredi 20 décembre 2017 - 09:40:10
Dernière modification le : jeudi 22 mars 2018 - 15:49:49

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Lucile Janvier, Pierre Olivier, Marie Blonski, Olivier Morel, Jean-Michel Vignaud, et al.. Correlation of SUV-derived indices with tumoral aggressiveness of gliomas in static 18F-FDOPA PET. Clinical Nuclear Medicine, Lippincott, Williams & Wilkins, 2015, 40 (9), pp.e429-e435. 〈10.1097/RLU.0000000000000897〉. 〈hal-01668458〉

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