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Biochip based on arrays of switchable magnetic nano-traps

Abstract : Magnetic biochips based on switchable magnetic nano-traps were developed and optimized so as to enable faster bio-assays via a reduction of steps and the efficient capture of analytes in a sample test solution. Nano-traps are based on snake shaped magnetic nanowires made by microelectronic technics from a thin magnetic layer. This optimized design ensures high local fields when the trap is activated and reduced stray fields when deactivated with respect to previous designs. Our proof-of-concept model consists to determine the anchorage of synthetic peptides in a bilayer enveloping magnetic beads by revealing their presence via fluorescently labeled immunoglobulins elicited against the native proteins of the said exposed peptides.
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Submitted on : Tuesday, January 23, 2018 - 6:09:35 PM
Last modification on : Friday, January 7, 2022 - 3:53:25 AM
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Christopher Vautrin, Maria Vyazmensky, Stanislav Engel, Stephan Mc. Murtry, Michel Hehn, et al.. Biochip based on arrays of switchable magnetic nano-traps. Sensors and Actuators B: Chemical, Elsevier, 2017, 251, pp.699-705. ⟨10.1016/j.snb.2017.05.084⟩. ⟨hal-01686947⟩



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