Skip to Main content Skip to Navigation
Journal articles

Comparing histological activity indexes in UC

Abstract : BACKGROUND: Assessment of disease activity in UC is important for designing an optimal therapeutic strategy. No single histology score is considered optimum. The aim of this study was to compare intraobserver reproducibility and the interobserver agreement of available histological UC activity indexes. METHODS: One hundred and two biopsy specimens (collected between 2003 and 2014) were scored blindly by three pathologists by determining Geboes, Riley, Gramlich and Gupta indexes and global visual evaluation (GVE). Intraobserver reproducibility and interobserver agreements for index and items of index were studied by intraclass correlation coefficient for quantitative parameter and by κ values and Krippendorff index for qualitative parameters. Relationship between indexes was studied by computation of Pearson's and Spearman's correlation coefficients. RESULTS: Geboes, Riley, Gramlich and Gupta indexes and GVE showed good intraobserver reproducibility and a good interobserver agreement. Histological items that showed the best interobserver agreement were 'erosion/ulceration or surface epithelial integrity' and 'acute inflammatory cells infiltrate/neutrophils in lamina propria'. The five scores were strongly correlated. CONCLUSIONS: Correlation between indexes is strong. Intraobserver reproducibility and interobserver agreement for all indexes is very good. Histological items that showed the best interobserver agreement are 'erosion/ulceration' and 'acute inflammatory cells infiltrate/neutrophils in lamina propria'.
Document type :
Journal articles
Complete list of metadatas

https://hal.univ-lorraine.fr/hal-01687696
Contributor : Ngere Ul <>
Submitted on : Thursday, January 18, 2018 - 4:34:59 PM
Last modification on : Tuesday, October 13, 2020 - 10:46:51 AM

Identifiers

Collections

Citation

Aude Bressenot, Julia Salleron, Claire Bastien, Silvio Danese, Camille Boulagnon-Rombi, et al.. Comparing histological activity indexes in UC. Gut, BMJ Publishing Group, 2015, 64 (9), pp.1412 - 1418. ⟨10.1136/gutjnl-2014-307477⟩. ⟨hal-01687696⟩

Share

Metrics

Record views

122