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The in vivo systemic effect of human recombinant interleukin-1 beta on fibronectin in rats.

Abstract : The in vivo systemic effect of interleukin (IL)-1 beta on plasma and cartilage fibronectin was studied in arthritic rats, as well as alpha 1-acid glycoprotein and albumin. Plasma fibronectin showed a 27% increase in the arthritic group, while alpha 1-acid glycoprotein increased 22-fold and albumin decreased by 46%. IL-1 effect depended on the administered dose. 2 micrograms injection significantly increased plasma fibronectin and alpha 1-acid glycoprotein. In cartilage, fibronectin was significantly modified in arthritic animals but increased in a dose-related manner after IL-1 treatment. As IL-1 increases fibronectin-degrading enzyme production and as some of these fragments can develop properties that do not possess the intact molecule, one can postulate a vicious circle in matrix degradation in the inflammatory process of the joint.
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https://hal.univ-lorraine.fr/hal-01707421
Contributor : Jean-Yves Jouzeau <>
Submitted on : Monday, February 12, 2018 - 5:51:20 PM
Last modification on : Thursday, November 7, 2019 - 2:02:01 PM

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  • HAL Id : hal-01707421, version 1
  • PUBMED : 1304431

Citation

X. Feng, J-Y Jouzeau, Geoffroy Durand, P. Netter, J. Labat-Robert. The in vivo systemic effect of human recombinant interleukin-1 beta on fibronectin in rats.. Clinical physiology and biochemistry, 1992, pp.55-61. ⟨hal-01707421⟩

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